ABSTRACT
The nasal cavity and paranasal sinsuses can modify the temperature and moisture content of inhaled air as well as provide protection against noxious gases and particulates. The dog is the only domesticated animal species in which the epidemiology of nasal cavity and sinuses (NCS) carcinoma has been described relative to a population at risk, providing a basis for comparison with the human experience. The nasal passages of the dog and man share many anatomic and physiologic characteristics; however, there are distinct species-specific traits. In domesticated animals, NCS tumors have been occasionally reported in buffalo, cattle, goats, and swine, and more frequently reported in horses, sheep, cats, and dogs. The geographic and temporal patterns of human NCS cancer in the U. S. are consistent with the presence of chemical and petroleum industries and furniture manufacturers. Several occupational and other exposures have been associated with NCS cancer in man.
