ABSTRACT
Most neuroblastomas arising in the nasal cavity occur in adults, in contrast to the more common pediatric tumors which with rare exceptions are located within the abdomen or thorax. This chapter suggests that a subdivision of the tumors on histologic grounds is not only feasible, but that it has important prognostic implications. Glands were associated with the tumor cells in almost half the sections of primary tumors, but they were rarely seen in recurrences. Tissue from 10 of the tumors was examined by electron microscopy. For the identification of a nasal neuroblastoma, or the recognition of a histologically similar neoplasm, good histologic material is essential, and in many instances electron microscopic study of the tumor cells is required. Olfactory rosettes are the hallmark of olfactory differentiation in a nasal neuroblastoma. A unique histologic finding in the neuroendocrine carcinomas was an admixture of glands throughout the tumor.
