ABSTRACT
Tumors were invasive and extension into the anterior cranial fossa was found in a number of animals. The experiment showed conclusively that the basal layer of the olfactory epithelium was the site of origin of esthesioneuroblastomas. This chapter focuses on conception of the site of origin and nature of nasal tumor, both in man and animal species, its light and ultrastructural pathology, as well as clinical aspects such as the sites of tumor involvement, presenting features, treatment and prognostic variables. In the original description of the tumor by Berger et al., the tumor was described as having a histologic pattern similar to tumors of the sympathetic ganglia and the adrenal medulla. The conception that the tumor arises from the neuroepithelial cells of the olfactory membrane is supported by the results of experiments performed at Free University in Amsterdam and reported by T. Bottema. The olfactory mucous membrane develops from the olfactory placode.
