ABSTRACT
This chapter focuses on sweat. The number of actively secreting eccrine glands depends on the body location of the type of sweat response created. Specific triggers of eccrine sweat include exercise, stress, thermal stress, mental stress, and emotional stress. Numerous methods have been developed to induce sweat and to collect samples from human skin. Sebaceous glands are lipid-secreting structures in the skin, especially in the scalp, forehead, and face. C. C. Peck et al. developed a mathematical model for the pharmacokinetics of transdermal drug detection. After wear, dry concentrates of the nonvolatile components of sweat, including drugs of abuse, remain on the collection pad of the sweat patch. The patch provides for continuous monitoring during the time of wear. In contrast, 4 or 5 urine specimens might be required to be comparable. Parallel urine specimens obtained at the time of patch removal gave positive results for 48 hr after drug use.
