Determination of Tissue Glutathione

The tripeptide glutathione (l-γ-glutamyl-l-cysteinylglycine) participates in numerous cellular functions. Glutathione is involved, for example, in the synthesis of proteins, ^{1 , 2} regulation of enzyme activity, ^{2 , 3} amino acid transport, ^{1 , 2} and the catabolism of reactive oxygen species. ^{3 , 4} Glutathione also serves as a coenzyme in the synthesis of endogenous compounds (e.g., leukotrienes) and the detoxification of exogenous compounds. ^{1 , 4}