ABSTRACT
Vascular complications in oncological patients are usually serious and may entail a higher morbidity/mortality associated with the neoplastic process. Complications due to vascular obstruction in advanced neoplasias can cause syndromes with complex therapeutic approaches (such as the Budd-Chiari or superior vena cava syndromes), as well as complications derived from chemotherapy due to cardiac, renal, or spinal cytotoxic effects, or from long-term radiotherapy-induced vascular lesions. However, the vascular pathology most often associated with neoplastic pathology is the venous thromboembolic disease, in which deep vein thrombosis may occur weeks or months prior to detection of the underlying neoplasia. Chemotherapy and antineoplastic hormone therapy have been associated with thrombotic and hemorrhagic cerebrovascular events. Some studies have found a larger incidence of cerebrovascular events with cisplatin, whereas tamoxifen is related with an increased risk of arterial and venous thromboembolism.
