ABSTRACT

Ovarian cancer accounts for 3%–4% of all female cancers and is the sixth most common cancer and still the most lethal gynaecological malignancy, with around 7,200 cases diagnosed in the UK in 2015 (1). Ovarian neoplasms are differentiated by the cell of origin: surface epithelial cells, germ cells, and stromal cells. Approximately 90% of primary ovarian cancers are epithelial tumours. The age distribution varies according to tumour histology; epithelial ovarian cancer is a disease of postmenopausal women, whereas germ cell tumours and sex cord-stromal tumours are most prevalent in the second and third decades of life.