ABSTRACT
Liquid Chromatography- Electrochemistry (LC-EC) provides a powerful tool for trace determinations, and is the fastest growing electro analytical technique. The most popular electrochemical detector cells are thin-layer devices in which the active electrode is imbedded in the wall of a channel formed by two blocks pressed around a thin gasket. Cyclic voltammetry rapidly provides useful information preliminary to LC-EC. This very convenient stationary-solution experiment easily duplicates those conditions found in the LC-EC detector cell. Series and parallel dual-electrode LC-EC provide many opportunities for study of drug metabolism because of the wide range of redox properties involved. Postcolumn chemical reactions coupled to electrode reactions are also expanding the range of LC-EC applications. Novel electrode materials, pre- and postcolumn reactions, and multiple working electrodes have extended the quantitative aspects of LC-EC while dramatically increasing the range of applicable compounds.
