ABSTRACT
For many pharmaceutical engineers the validation and operation of heating, ventilating, and air conditioning (HVAC) systems serving their manufacturing areas can be a vexing problem. This chapter introduces some practical information that help the HVAC engineer design a reliable, properly performing air handling system. The construction cost for HVAC systems serving aseptic spaces is considerable. Costs in the range of $120.00 to $180.00 per square foot or more for state-of-the-art systems are common; thus, the need to hold these costs in check is mandatory. The successful design and construction of HVAC systems for cleanroom control requires a greater attention to detail and quality than normally exists for a standard commercial building. Positive pressurization of clean rooms with respect to adjacent spaces is a "must" as stated in the Aseptic Guideline. Cleanroom HVAC systems are by nature high noise generators. The resultant noise can be quite objectionable and should be attenuated.
