ABSTRACT

Acknowledgments ................................................................................................................. 33

References ............................................................................................................................. 33

Although the detailed mechanisms of the enhanced stability of Stealth® liposomes injected in the human body are not yet fully understood, there is no doubt that they have to be related to the layers of poly(ethyleneglycol) chains attached to the liposome membranes, which oppose a steric barrier against the attacks of the diverse elements of the immune system. These steric effects are well known in the field of colloid science and technology, where they are used to insure the stability of colloidal dispersions. The aim of this chapter is to review briefly the physical description of these effects.