ABSTRACT
This chapter discusses absorption and transport, functions, sources, requirements and safety, and research findings on efficacy of vitamin E. Clinical vitamin E deficiency has been documented in individuals with a chronic malabsorption syndrome, patients on total parenteral nutrition, and premature infants. Improvement of neurological function has been documented with appropriate vitamin E therapy; progressive neurological damage may be prevented in children with prolonged cholestatic disease by early initiation of vitamin E therapy. Results of animal bioassays and human studies have demonstrated that the biological potency of natural forms of vitamin E is higher than that from synthetic sources. Adult vitamin E requirements may vary at least fivefold, depending on dietary and lifestyle habits and/or tissue composition from previous intake patterns. The potential protective role of vitamin E in preventing or minimizing free radical damage associated with cardiovascular disease, cancer, premature aging, cataract, and air pollution has been under investigation.
