ABSTRACT
This chapter focuses on processes occurring in biological systems. It describes the lipid peroxidation induced by metal ions. Differences in the toxicities of metal ions can also be related to differences in solubility and transport in the body. The chapter develops the possible involvement of metal ions during the whole process of lipid peroxidation. It considers the consequences on the evaluation of lipid peroxidation and on tissue damage. Metals ranging from a few nontransition (lead, cadmium, mercury) to many transition elements (vanadium, chromium, iron, nickel, copper, silver) have been reported as capable of inducing oxidative stress and especially lipid peroxidation. The author suggests the involvement of lipid peroxidation in the toxicity associated with these metals. Multiple mechanisms are also involved for a given metal. Further research is needed to delineate the specific roles of lipid peroxidation in the pathogenesis of metal ion toxicity and to determine the possible treatment by various antioxidants of individuals who are intoxicated with these metals.
