ABSTRACT
Bioadhesion is a technical innovation developed in order to improve the bioavailability and efficiency of various active ingredients. This method can be applied to solid or viscous dosage forms, but most of the studies concern tablets. Today, many bioadhesive polymers have been investigated, among which the most widely used is poly(acrylic acid). The formulation has to take into account the nature of the mucosa on which the tablet is to adhere and the type of activity required (local or systemic). It also has to consider the duration of release desired, and must therefore combine a matrix system with a bioadhesive polymer. The evaluation of such dosage forms is dual: bioadhesive potency (by tensile tests) and drug release (by dissolution and in vivo tests).
