ABSTRACT
Use of graft copolymers as nonthrombogenic material is very practical, because it is not difficult to modify a conventional polymer in such a way that the trunk of the graft copolymer provides mechanical support and the side chains provide nonthrombogenicity. Various kinds of nonthrombogenic polymers are introduced briefly, and the synthesis and application of heparinized graft copolymers and hydrophilic graft copolymers having poly(ethylene oxide) side chains are described. Particularly, for the latter polymer, correlation between platelet adhesion and plasma protein adsorption is discussed.
