ABSTRACT
A review of recent research on the interrelation of protein adsorption and blood compatibility is presented. The mechanism of surface passivation, determined by the physicochemical properties of the biomaterials, is considered. Also analyzed is the influence of the composition and structure of the adsorbed protein layer on short-and long-term processes such as blood and tissue cell reaction, throm-bosis, thromboembolization, infections and inflammatory response, and calcification. Up-to-date approaches to the development of blood-compatible biomaterials are analyzed, based on the regulation of their adsorptional characteristics.
