ABSTRACT
Introduction
Discovery of the Activation by GSH of the Feeding Response in Hydra
Quantification of the GSH-Activated Feeding Response in Vivo
Description and Measurement of the Feeding Response
Some Properties of the Feeding Response
Kinetics of the GSH-Activated Feeding Response
Determination of the Apparent Dissociation Constant
In Vivo Determination of the pH Profile of the Glutathione Receptor
Conformation of GSH at the Receptor Site
Earlier Work on the Active Structure of Glutathione
Position-3 (Glycine) Analogs
Position-2 (Cysteine) Analogs
Conformation of the 1 Position (γ-Glutamyl) Needed for Activation
Other Behavioral Responses in Cnidarians Activated by GSH or by Specific Amino Acids
On the Evolution of Receptor Sites to Peptides and Amino Acids in More Complex Organisms
Conclusions
References
