ABSTRACT
Lipoplexes present numerous advantages in gene delivery (9,13,20): (a) lipoplexes can protect DNA or RNA from inactivation or degradation in biological milieux; (b) lipopexes can carry large pieces of DNA, potentially up to chromosome size; (c) they are not immunogenic; (d) they are safe relative to viral vectors; (e) large-scale production of liposomes is easy compared to that of viruses; (f) they are highly versatile.
