ABSTRACT
Dopamine (DA) is an important chemical messenger in the central nervous system. Understanding the mechanisms and kinetics of DA neurotransmission is necessary to discern the role of DA in many biological functions, including locomotion, motivation, pathologies such as Parkinson disease, and the use of drugs of abuse. The investigation of DA neurotransmission poses challenges that are common in analytical chemistry: selectivity and sensitivity. In addition, biocompatible sensors that are both rapid and small are needed. Background-subtracted cyclic voltammetry at carbon-fiber microelectrodes represents an excellent tool to address these challenges in brain slices.
