Figure 5 Schematic of presynaptic mechanisms involved with the uptake of dopamine (DA). MAO, monoamine oxidase (located on the surface of the mitochondrion); VMAT, vesicular monoamine transporter DAT dopamine transporter. Cellular machinery has been enlarged to show detail.

doi:10.1201/9780203908907-112

Chapter

Figure 5 Schematic of presynaptic mechanisms involved with the uptake of dopamine (DA). MAO, monoamine oxidase (located on the surface of the mitochondrion); VMAT, vesicular monoamine transporter DAT dopamine transporter. Cellular machinery has been enlarged to show detail.

Chapter

ABSTRACT

As previously discussed, the simultaneous measurement of O2 levels and DA concentrations is possible by scanning the electrode first sufficiently positive to oxidize DA, and subsequently negative enough to reduce O2 [17]. The investigation of O2 consumption is important because oxygen is necessary for normal brain function and is an index of energy use. The process of neurotransmission consumes energy and thus

there should be a link between it and O2 levels. With an electrical stimulation typical of studies in brain slices (2 pulses at 10 Hz, 480 µA) an immediate, short-lived rise in DA concentration is observed that quickly