![saline, (B) 100 µM L-DOPA, (C) 100 nM reserpine, and (D) 100 µM L-DOPA and 100 nM reserpine for 90 min. A portion of the nucleus can be seen for the cells shown in A and B (at the top and bottom, respectively). Scale bars in each figure represent 500 nm. (Reproduced from J. Neurosci. with permission [57].)](https://images.tandf.co.uk/common/jackets/crclarge/978082470/9780824707316.jpg "saline, (B) 100 µM L-DOPA, (C) 100 nM reserpine, and (D) 100 µM L-DOPA and 100 nM reserpine for 90 min. A portion of the nucleus can be seen for the cells shown in A and B (at the top and bottom, respectively). Scale bars in each figure represent 500 nm. (Reproduced from J. Neurosci. with permission [57].)")
ABSTRACT
L-DOPA, a dramatic increase in the volume of the dense core vesicle halo results (Figure 25B). When the cells are treated with reserpine, a significant decrease in the size of the vesicle halo is apparent (Figure 25C). Similar to the amperometric results, no significant change in vesicle volume results when PC12 cells are simultaneously treated with both drugs (Figure 25D). In addition, neither drug significantly affects the volume of the dense core itself.
