ABSTRACT
CE as a separation method has several advantages for the analysis of biological samples. Injection volumes are very small (nanoliter to picoliter), allowing the analysis of limited volume samples. Due to the plug flow associated with CE, it is possible to obtain rapid, highly efficient separations by applying a high field across the fused silica capillary. Separation selectivity can be adjusted by changes in pH or through the use of modifiers. The pH range is larger than that which can be used with most silica-based chromatography columns. Due to the small volume of run buffer needed for the separation, exotic additives that would be too expensive for LC-based separations can be employed.
