ABSTRACT
Microdialysis is a technique capable of monitoring drugs and neurotransmitters in vivo [63]. Figure 11 shows a typical microdialysis sampling system. A probe consisting of a dialysis membrane is implanted in the tissue of interest. A solution of ionic strength similar to that of the extracellular fluid of interest is slowly perfused through the dialysis probe. Compounds that are in the extracellular fluid diffuse through the dialysis membrane and are pumped to the fraction collector. To obtain maximum recovery of analyte through the probe, very slow flow rates are generally employed (0.1-1 µL/min).
