Figure 12 Typical microdialysis probes for various tissues of rats or similar-size animals. (A) intracerebral guide cannula and rigid concentric cannula probe for brain tissue, (B) linear probe used for sampling peripheral tissues such as liver, muscle, dermis, tumor, kidney, (C) vascular probe for sampling from the jugular vein, and (D) shunt probe for sampling from the bile duct. Unlabeled arrows indicate direction of dialysate flow into and out of probes. (Courtesy of Bioanalytical Systems Inc.)

doi:10.1201/9780203908907-210

Chapter

Figure 12 Typical microdialysis probes for various tissues of rats or similar-size animals. (A) intracerebral guide cannula and rigid concentric cannula probe for brain tissue, (B) linear probe used for sampling peripheral tissues such as liver, muscle, dermis, tumor, kidney, (C) vascular probe for sampling from the jugular vein, and (D) shunt probe for sampling from the bile duct. Unlabeled arrows indicate direction of dialysate flow into and out of probes. (Courtesy of Bioanalytical Systems Inc.)

Chapter

Figure 12 Typical microdialysis probes for various tissues of rats or similar-size animals. (A) intracerebral guide cannula and rigid concentric cannula probe for brain tissue, (B) linear probe used for sampling peripheral tissues such as liver, muscle, dermis, tumor, kidney, (C) vascular probe for sampling from the jugular vein, and (D) shunt probe for sampling from the bile duct. Unlabeled arrows indicate direction of dialysate flow into and out of probes. (Courtesy of Bioanalytical Systems Inc.)

ABSTRACT

Off-line analysis of microdialysis samples was first used to monitor the pharmacokinetics of L-dopa [65]. In this example, a flexible probe was employed for I.V. microdialysis sampling. The probe was perfused at 1 µl/min. Five microliter samples were collected for analysis, leading to a temporal resolution of 5 min. The concentration of L-dopa in the blood was monitored for over 2 hr with microdialysis sampling, and the half-life of the drug was determined to be 10 min.