ABSTRACT
Different biocatalyzed transformations proceed with single-stranded or double-stranded DNA assemblies. The ligation of nucleic acids, replication of double-stranded assemblies, or the sequence-specified scission of the double-stranded system by specific endonucleases are a few representative examples. Bioelectro-catalytic transformations occurring on surfaces provide additional nanometric tools to manipulate and nanoengineer the nucleic acid surfaces and to amplify the sensing processes by the replication route. The different electronic transduction means that follow the surface functionalization by DNA may then be applied to follow the biocatalyzed transformations occurring on the nucleic acid-functionalized supports.
