ABSTRACT

Electron microscopy is a valuable adjunct to research and development functions of the pharmaceutical industry. As presented in this chapter, the applications benefiting from electron microscopy are not only extensive but persist throughout the course of drug development. From early in the Drug Discovery stages to understand and characterize molecular targets and validate the effects of drugs in cells and tissues, through Drug Development to assess dissolution and stability of formulations and to identify safe therapeutic doses, and, finally, in marketing to evaluate the integrity of protective packaging materials, electron microscopy is of vital importance to the pharmaceutical industry.