ABSTRACT
The systematic name and number for prolyl 4-hydroxylase are 4-proline:2-oxo-glutarate dioxygenase and EC 1.14.11.2, respectively.
(1)
II. PHYSIOLOGICAL IMPORTANCE
The formation of hydroxyproline is necessary for the intracellular assembly of procollagen polypeptide chains into helical structures. When collagen chains are underhydroxylated, helical formation is impaired and collagen is retained within the cell. As a consequence, underhydroxylation of collagen leads to decreased collagen production (1-3, 6). In plants, increased hydroxyproline-rich glycoprotein synthesis is associated with wound healing and resistance to fungal infections. Impaired hydroxylation impairs the ability to respond to infections and wounds, particularly situations wherein encapsulation of a foreign substance is a requisite (5).
