ABSTRACT
Libraries of peptides and oligonucleotides were relatively easy to handle both in the mixture and in the individual one-bead-one-compound format. Determination of structure of peptide and/or oligonucleotide is made relatively easy by sequencing requiring picomolar or even lower amounts of material. At the same time synthetic methodologies for their synthesis are well developed. However, a good candidate for new successful drug is being sought between “small organic molecules.” Libraries containing nonoligomeric organic compounds were obviously the next step in the development of combinatorial chemistry. Jonathan Ellman recognized this need and developed a method for solid-phase parallel synthesis of benzodiazepines [28]. His publication, together with published results from Parke-Davis [29] and Chiron [30,31], started a flood of communications about application of solid-phase synthesis to preparation of enormous numbers of different categories of organic compounds, with the major focus on heterocyclic molecules. (Numerous compilations of solid-phase syntheses were published; see, for example, [32-35], and a dynamic database of all relevant publications is available on the Internet (https://www.5z.com/divinfo).).
