ABSTRACT
The concept of polymer-supported synthesis for molecules other than peptides was investigated in the late 1960s and early 1970s by a number of investigators who helped to define the scope and limitations of polymer-bound synthesis of organic molecules [2,3]. There are a number of advantages to polymer-bound synthesis. As mentioned above, the main advantage of an insoluble polymer support is that the insoluble polymer may be isolated from a reaction solution by filtration, making conventional purification of the desired compound unnecessary. This simplified purification procedure allows the use of a large excess of reagents to drive a reaction to completion while minimizing the time needed to purify and isolate the desired product from the complex reaction solution.
