ABSTRACT

The hydroxyl functional group also offers a handle for linking a scaffold to a suitable polymer support. This technique has been a useful synthetic strategy for those libraries where a free hydroxyl group is desired in all members of the library. The solid-phase synthesis of hydroxyethylamine aspartyl protease inhibitor libraries and prostaglandin libraries are excellent examples of this strategy (Fig. 3) [51-53]. The hydroxyl group is an integral part of the aspartyl protease inhibitor