ABSTRACT
As described for high-performance liquid chromatography (HPLC), by far the most widely applied ionization method used in interfacing CE to mass spectrometry for the analysis of biomolecules is electrospray ionization. An uninterrupted electrical contact is essential for both the continued operation of the CE and for the generation of the electrospray when interfacing CE with ESI-MS. Several interfaces have been developed to achieve this electrical contact. The three most widely applicable interfaces are liquid junction, sheath liquid, and sheathless interfaces.
