ABSTRACT

How might cellular knowledge be best visualized and probed by the user? One common way to represent cellular knowledge is through pathway diagrams. There are many welldefined metabolic and signaling pathways, but, in isolation, they have lost their physiological context. In reality, pathways often intersect with other pathways to form networks of molecular interactions. Within the Cellomics Knowledgebase, a pathway is a collection of transformations. This collection contains the same functional units and transformations as defined in a well-known pathway, and it can be generated de novo from a database query. Hence, we use the term “molecular wiring diagrams” instead of “pathway diagrams.”