The goal of proteomics can be defined as the identification of all the proteins encoded in the human (or any other) genome followed by the determination of (1) their range of expression across the different cell types that constitute the various (human) tissues; (2) their subcellular localization; (3) their post-translational modifications; (4) their interaction with other proteins, and (5) their structure-function relationships. Additionally, there exists the need for developing an understanding of the global and temporal expression patterns at different developmental, physiologic, and pathologic states. The implications of such an undertaking for biomedicine are tantalizing, as they range from accelerating drug discovery to the early detection and therapy of cancer and other diseases, just to name a few applications.