Experiments designed to explore the actual physical reality of the interaction of analyte, mobile phase, and stationary phase are fraught with practical limitations that impede drawing significant conclusions from the results. It has been easier for most practitioners to foster the folklore forged through the citation generations of HPLC literature than to refine the “cartoon-model” view of the chromatographic process to a higher “art.” In the spirit with which, Phyllis Brown reminds us, Calvin Giddings envisioned this Advances series, perhaps it is time now to introduce a new order into our chromatographic thinking and encourage future investigation.