ABSTRACT
Parkinson’s disease (PD), like other neurodegenerative disorders, is clinically heterogeneous (1). Age of onset, the relative prominence of certain signs and symptoms, course and rate of progression, and the responsiveness to therapy are variable but still assist in differentiating it from atypical forms of parkinsonism (2). Mainly described by its cardinal motor manifestations (bradykinesia/akinesia, rigidity, resting tremor, and postural instability), progression is inevitable, as there is a continuous loss of nigrostriatal dopaminergic neurons in the substantia nigra pars compacta (SNpc) (3).
