Nucleic Acids and Their Derivatives

Numerous studies have reviewed the technical background of thin-layer chromatography (TLC; planar or flatbed) (1), which developed under the guidance of Ismailow and Schraiber in 1938 and may date back to Friedlieb Ferdinand Runge (1850). The complexities of the early systems were refined by Stahl (1958-1960), and these breakthroughs began an immense contribution to the understanding of nucleic acid chemistry (2). The early papers of Ismailow, Schraiber, and Stahl were translated and reproduced by Pelick et al. (3).