ABSTRACT
The enormous acceleration of reaction rates that enzymes provide is one of the foundations of life as we know it. For many years, the study of metabolic enzymes, their reactions, and the way that ATP is generated has been the main focus of enzymology (1). However, classic metabolism is only the most well-known function that enzymes perform. The enzymes that participate in DNA repair, transcription, and replication, and the enzymes that play roles in signal transduction and cell morphology control, are examples of often bigger and more complicated enzymes and enzyme complexes that are currently being studied intensely (2-4). Therefore, it is not hard to find a good reason to study how enzymes work, and, consequently, there is a steady flow of information on new enzymes, their substrate specificities, catalytic mechanisms, and cellular roles in current biological journals.
