ABSTRACT

The application of enzymes, especially in organic synthesis, is now well documented in literature (1-4). Biocatalytic processes are, however, not new as the first examples are more than 100 years old, i.e., the use of an oxynitrilases for the synthesis of L-arabinose was reported back in 1894 (5). In the last century many processes have been developed based on enzymatic reactions for the production of a plethora of products, such as citric acid, amino acids, antibiotics, etc. However, the majority of them used whole cell systems. Only in the last two decades did the use of isolated enzymes become more and more important, and again new processes have found their way into industry (6-8).