ABSTRACT
COCH (coagulation factor C homology) was identified as a novel sequence isolated initially as a partial transcript from a second-trimester human fetal cochlear (membranous labyrinth) cDNA library (developmental ages 17-19 weeks) (1). Its identification was through an organ-specific approach to gene discovery in the auditory system. Subsequent chromosomal mapping of expressed sequences in the inner ear from this method provides candidate genes for deafness disorders localized in coincidental regions.
