ABSTRACT
If compared with normal intakes, phytosterol doses used in animal trials are substantially higher and correspond to even higher intakes than that from phytosterolenriched food products (31,32). The doses in animal trials are difficult to translate directly into human conditions, but compared as dose/kg body weight (BW), the protective effects on growth and spread of prostate cancer were seen with a dose of 2.6g/kg BW−1 d−1 (calculation based on 2% phytosterols, 2.57g of food per day, BW=20g), which corresponds to that of 200g of phytosterols per day for a 75-kg person (23). The phytosterol dose in the benign prostatic hyperplasia trial (114) was relatively small and would only correspond to a 20-50% increased dietary intake of phytosterols (117,118). Functional food products with cholesterol-lowering properties increase the intake as much as 7-20 times (32), which suggests that these could have a stronger physiological effect.
