ABSTRACT

Metabolomics is the computing of emergent properties of biological systems such as development, biological clocks, and infection processes from kinetic models of DNA, RNA, and proteins. These kinetic models are used to guide the process of gene-validated product discovery to transform medicine, industry, and agriculture. The ultimate challenge of genetics is to predict global properties of the organism, properties not necessarily manifested by individual subcomponents within the cell. Some of these properties only make sense with respect to the organism as a whole (e.g., pathogenicity lifestyle [1]) or life itself. These complex traits controlled by many genes represent the ultimate challenge in seeking an explanation in terms of detailed molecular mechanisms in the cell.