ABSTRACT
Lower limb ulcer management remains one of the most challenging parts of vein care. The clinical context of Klippel-Trenaunay syndrome makes this challenge even more difficult to be properly managed, particularly considering the paucity of literature on the topic. Making a risk/benefit evaluation in this scenario becomes extremely difficult. Sparse evidence provided mainly by case reports suggests the possibility of attempting treatments by minimally invasive lasers that promote tissue biostimulation or of administering innovative antiangiogenic drugs or of performing reconstructive surgical vascular procedures. Until more evidence is gathered, it is the authors’ opinion that considering also the possibility of worsening the initial Klippel-Trenaunay syndrome presentation, a conservative management based on proper graduated compression and adequate lifestyle is to be chosen.
