ABSTRACT
Pancreatitis in Japan........................................................................ 208 11.3 Generation and Analysis of PSTI Knockout Mice......................... 210 11.4 Functional Analysis of Recombinant PSTI Proteins with
Amino Acid Substitution ................................................................. 212 11.5 Epilogue............................................................................................ 214 References .................................................................................................. 215
Inappropriate activation of trypsinogen in the pancreas leads to the development of pancreatitis. Once activated, trypsin is capable of activating many other digestive proenzymes in the pancreas and enhances autodigestion of the pancreas. Trypsin also activates cells via trypsin receptor, which has recently become known as one of the protease activated receptors, namely PAR-2. Both acinar and duct cells express abundant PAR-2.
