ABSTRACT
Transplantation.................................................................... 357 18.1.2 Lineage Switches of Cells — Definitions ......................... 357 18.1.3 Pancreatic Hepatocytes ...................................................... 358
18.2 Experimental Models of Pancreatic Hepatocytes .......................... 358 18.2.1 Hamster Model.................................................................... 358 18.2.2 Mouse Model ...................................................................... 359 18.2.3 Rat Models........................................................................... 359
18.2.3.1 Ciprofibrate Model.............................................. 359 18.2.3.2 Methionine-Deficient Diet Model ...................... 360 18.2.3.3 Dichloro-P-Phenylenediamine Model................ 360 18.2.3.4 Cadmium Chloride Model.................................. 360 18.2.3.5 Spontaneous Hepatocyte Development............ 360 18.2.3.6 Copper-Deficiency Model .................................. 360
18.3 Origin of Pancreatic Hepatocytes................................................... 368 18.3.1 Ductular and Oval Cells as the Progenitor Cells of
Pancreatic Hepatocytes....................................................... 368
18.3.2 Differentiation Potential of Oval and Ductular Cells —
In Vitro
and
In Vivo
Studies......................................... 369 18.4 Possible Mechanisms Involved in the Induction of Pancreatic
Hepatocytes...................................................................................... 370 18.5 Epilogue............................................................................................ 371 Acknowledgments...................................................................................... 371 References .................................................................................................. 371
Multicellular organisms are composed of a multitude of differentiated cells that exhibit unique structures and specialized functions. The development of differentiated cells from the fertilized egg through pluripotent embryonic stem cells is meticulously controlled by transcription factors, growth and differentiation factors, cell-cell interactions, and the extracellular matrix components.
