ABSTRACT
Model................................................................................................ 494 25.6 Molecular Genetics .......................................................................... 495 25.7 Familial and Hereditary Pancreatic Cancer — Classification ....... 495 25.8 PJS and PC ....................................................................................... 495 25.9 FAMMM Syndrome and PC............................................................. 496 25.10
BRCA2
Mutations in Familial Pancreatic Cancer........................... 500 25.11 Pancreatic Acinar Cell Carcinoma .................................................. 504 25.12 Pancreatic Endocrine Tumors ......................................................... 504 25.13 Clinical Findings .............................................................................. 505
25.13.1 Multiple Endocrine Neoplasia Type 1 (MEN 1)............... 505 25.13.2 Insulinomas ......................................................................... 507 25.13.3 VHL Disease........................................................................ 507
25.14 Genetic Counseling ......................................................................... 508
25.15 Epilogue............................................................................................ 508 25.15.1 Knowledge Gleaned from Study of Genetics of Breast
and Colon Cancer and Their Influence on PC ................ 509 25.15.2 Surveillance and Management of PC ................................ 510
Acknowledgments...................................................................................... 510 References .................................................................................................. 511
The projected incidence of pancreatic cancer (PC) in the United States is 32,180 for 2005, with an expected mortality of 31,800.
