ABSTRACT
Neural grafting, as neural transplantation is also known, involves the transfer of some type of neural tissue from one place to another. Fetal material harvested from litters of rats, cats, and individual monkey embryos have been widely used for elucidating the mechanisms by which neural grafts can ameliorate nervous system dysfunction. Animals of species ranging from frogs and salamanders to macaques and man have undergone neural transplantation; the procedures described are for the rat, but are generally applicable to all mammalian species. Since the successful grafting of neural tissue often depends on the accuracy of the implantation in the host, such transfer should be done with as much precision as possible. Immunosuppression, common in other organ transplantation to prevent tissue rejection, has been demonstrated to increase survival of neural grafts in many cases as well. Neural grafting is a powerful tool in itself for investigating questions of development and regeneration.
