ABSTRACT
Until recently, estimation of exposure to exogenous carcinogens has largely been a process of environmental sampling to determine peak or average ambient concentrations combined with a calculation of probable intake as a function of the route of exposure. A potentially more accurate approach is the quantification of carcinogen-protein adducts formed with readily accessible proteins, such as hemoglobin, which could serve as in vivo dosimeters [1], This paper will discuss some of our recent efforts in developing this approach for the dosimetry of one group of structurally related compounds, the aromatic amines.
