ABSTRACT
Genital infections with Chlamydia trachomatis are the most common bacteria-associated sexually transmitted infections reported. For non-culture techniques, swabs used for sample are collected in a similar fashion. When tested by microparticle EIA urine testing on first void urine was 81.3% sensitive and 95.7% specific as compared to urethral swab culture. In a four-center study, comparing LCR examination of first void urine in women against culture from an endocervical swab, as measured against an expanded gold standard, sensitivity and specificity of first void urine was 93.8 and 99.9%, respectively. In some studies the sensitivity of chlamydia tissue culture has ranged from 33 to 86%. Because poliovirus infection induces a strong mucosal immune response in primates and humans, these results indicate that poliovirus-chlamydia hybrids could become powerful tools for the study of mucosal immunity to chlamydial infection and for the development of recombinant chlamydial vaccines.
