ABSTRACT
A variety of humoral substances are known to activate the inhibitory cardiac receptors and elicit Bezold-Jarisch-like responses. In the face of a fall in blood pressure, the systemic arterial baroreflexes will attempt to increase pressure by increasing peripheral resistance and cardiac output and do the opposite when blood pressure is rising. Several stimuli are known to cause the release of prostaglandins are one of the naturally occurring substances in the body that can activate the inhibitory cardiac receptors. Administration of veratridine into the coronary circulation results primarily in the stimulation of inhibitory cardiac receptors as evidenced by the bradycardia and hypotension that has been reported by others in anesthetized and conscious animals. H. M. Coleridge et al., however, could stimulate separate endings with mechanical probing and chemicals such as veratridine, nicotine, and capsaicin to obtain similar hemodynamic results; i.e., hypotension and bradycardia.
