ABSTRACT

Infection is a well-recognized complication of hematopoietic istem cell transplantation (HSCT). Based on decades of cumulative experience from HSCT for hematologic malignancy, there are relatively defined periods of risk for infection in the transplanted host. 1-5 Vulnerability to infection is dynamic and is dependent upon the baseline immune status and underlying diseases, specific procedures and treatments related to the transplant regimen, and post-transplantation factors that influence immune reconstitution such as the development of graft versus host disease, the presence of opportunistic infection (OI), or the need for ongoing immunomodulating therapies.