ABSTRACT
The discovery of endozepines is a perfect example to illustrate how receptor binding techniques are one of the main tools that we have in order to achieve pharmacological discoveries. Benzodiazepines have been in medical use since the 1960s to treat conditions such as anxiety. However, up to the early 1970s, their precise mechanism of action to induce their antianxiety effects was unknown. Benzodiazepines are not naturally occurring compounds. In fact, these compounds were developed in a serendipitous way. The presence and function of the diazepam binding inhibitor/acyl-CoA binding proteins have been demonstrated in various insect species. Development is one of the most interesting and mysterious processes in all of biology, and metamorphosis is a fascinating subset of developmental biology. Arguably one of the most dramatic examples of metamorphosis is insect metamorphosis.
